3D fractional moving blood volume (3D-FMBV) demonstrates decreased first trimester placental vascularity in pre-eclampsia but not the term, small for gestation age baby.

3D fractional moving blood volume (3D-FMBV) demonstrates decreased first trimester placental vascularity in pre-eclampsia but not the term, small for gestation age baby.

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OBJECTIVE:To undertake an observational study to see whether first trimester placental vascularity, measured with a standardized power Doppler index: 3D-FMBV, is different in pregnancies which either develop pre-eclampsia or lead to term, normotensive small for gestational age (SGA) babies.METHODS:Women were scanned between 11 and 13+6 weeks.The placental volume (sPlaV) was estimated using our previously validated semi-automated tool.Estimates of 3D-FMBV were generated from the raw power Doppler signal for the whole utero-placental interface, UPI (FMBV-UPI) and 5mm into the placenta (FMBV-IVS).

Differences in the placental volume and FMBV for pregnancies developing pre-eclampsia Sarsaparilla Smilax and resulting in term, normotensive SGA babies were compared with term, normotensive, appropriate for gestational age (AGA), controls.RESULTS:Results were available for 143 women.The placental volume (sPlaV) was reduced in both pre-eclampsia (p = 0.007) and term, normotensive SGA (p = 0.

001) when compared with term normotensive AGA controls.3D-FMBV estimates were significantly lower for pregnancies developing pre-eclampsia (FMBV-UPI, p = 0.03, FMBV-IVS, p = 0.01) but not for the normotensive SGA pregnancies (FMBV-UPI, p = 0.

16, FMBV-IVS, p = 0.27).CONCLUSION:Pregnancies destined to develop pre-eclampsia are more likely to have small placentas with significantly reduced Accessories vascularity at 11-13 weeks.Those pregnancies which were normotensive throughout but resulted in an SGA baby delivered at term, had significantly smaller placentas but with similar vascularity to normotensive AGA pregnancies.